PFA are a group of synthetic chemicals known for their water- and oil-repellent properties. PFA are not commonly used in skincare products or cosmetics because of concerns about their safety and potential health risks. Their use in personal care products is generally discouraged or regulated in many countries because of their persistence in the environment and potential adverse effects on health. Efforts are underway to restrict the use of certain PFA compounds and find safer alternatives in consumer products like cosmetics and skincare.